Zoloft is an SSRI (selective serotonin reuptake inhibitor), which
is thought to work by increasing the amount of serotonin (a chemical
involved in communication between nerve cells) available to the
brain, back to a normal level. Zoloft has been
shown to be effective in relieving several kinds of emotional
disturbance that decrease the ability to function normally. This
- Panic attacks
- Posttraumatic stress syndrome
- Obsessive-compulsive disorder
- Fibromyalgia (in low doses)
- Severe PMS or Pre-menstrual Dysphoric Disorder (PMDD)
Zoloft 50 mg, brand name Besitran, is manufactured by Pfizer and comes in packs of 30 tablets.
Zoloft side effects are usually temporary and rarely cause a
level of discomfort that causes patients to want to stop treatment.
Consult your physician for advice on how to alleviate side effects
that persist or bother you.
Zoloft side effects: sweating, agitation, dry mouth, decreased
appetite, somnolence (drowsiness), dizziness, insomnia, tremor,
constipation, indigestion, diarrhea, decreased libido, yawn,
nervousness, sexual side effects, or weight loss.
Avoid operating a vehicle or other heavy machinery
until you know how you react to Zoloft. Zoloft side effects may
include impaired thinking and motor skills, or blurred vision.
Dependence: Zoloft has not been seen to cause dependence or
Cautions: Zoloft should be used cautiously in patients
with: manic disorders, blood circulation and metabolism
difficulties, or a history of seizures. Zoloft may not be right for
patients with brain damage or disease, or congenital brain defects.
Zoloft dosages should be lower for patients with kidney or liver
trouble. Zolof has not been studied in patients with heart disease.
Tell your doctor if you have ever had an allergic reaction to
Zoloft, or any other medication.
Certain medications and supplements may increase the risk of
serotonin syndrome in combination with Zoloft. Serotonin syndrome
may cause confusion, restlessness, lowered coordination, shivering
or trembling, diarrhea, fever, sweating, twitching, or behaving with
an excitement you can't control. If you experience a cluster of
these symptoms, and you suspect that it may be due to a drug
interaction or overdose, seek medical attention immediately.
Zoloft may not mix well with all other medications, either
prescription or over the counter. Some medications should not be
mixed at all, and with others your doctor may want to adjust your
dose to decrease the risk of side effects. Consult with your doctor
if you are already taking, or intend to take, any of the following:
- Alcohol - While Zoloft and alcohol have not been shown to
interfere with each other, but taking them together is not
- Appetite suppressants like
- Benzodiazepines such as lorazepam, diazepam,
triazolam, temazepam, chlordiazepoxide,
clorazepate, halazepam, estazolam, clonazepam
should probably not be mixed with Zoloft.
- Beta Blockers - Drugs like propranolol, metoprolol, atenolol, and others may build up in the body to
toxic levels when combined with SSRIs.
- Cough medicine (dextromethorphan) or any over the counter cold
- Coumadin (warfarin) - may
cause bleeding problems when used with Zoloft. Your doctor may
prevent this by adjusting the dosage of one of these
- When used with Zoloft, increases the chance of developing
- Aastemizole - May alter your heartbeat if used with
- Moclobemide - This medication should not be mixed
with Zoloft, and you should allow a week following the use of
modobemide before starting Zoloft. Allow 2 full weeks after
stopping Zoloft before beginning use of modobemide. Serious
side effects, including serotonin syndrome can develop.
- MAO inhibitors - Zoloft must never be mixed with MAO
(monoamine oxidase) inhibitors, a class of antidepressants and
antisenility drugs, such as selegiline, furazolidone, phenelzine, isocarboxazid, or tranylcypromine.
Never use Zoloft within 2 weeks of starting or stopping an
MAO inhibitor. Patients over 65 years of age should allow a longer wait
period between using Zoloft and an MAO, as Zoloft may stay in
their system longer than in other patients.
- Migraine medications of the triptan class such as naratriptan,
sumatriptan, rizatriptan, or zolmitriptan can cause
coordination difficulties when mixed with SSRIs.
- Narcotic/opioid analgesics like Cialis, meperidine, buprenorphine, propoxyphene, hydromorphone, morphine, nalbuphine, oxycodone,
oxycodone with acetaminophen, butorphanol, pentazocine, or hydrocodone
with acetaminophen), hydrocodone with ibuprofen.
- Bromocriptine should be mixed cautiously with
- Sedatives like butalbital, phenobarbitol, seconal, or other barbiturates.
- Selective serotonin reuptake inhibitors (SSRIs) of any other
type, like citalopram,
fluoxetine, fluvoxamine, or paroxetine.
- Carbidopa, levodopa)
- Sleep medication like zolpidem, zaleplon, or over the counter sleeping pills should
be used with Zoloft only as, and if, advised by your doctor.
- Street drugs such as LSD, Ecstasy (MDMA), or marijuana. These
drugs also affect serotonin levels in the brain and may react
strongly with an SSRI like Zoloft.
- Thioridazine - Severe Zoloft interactions can occur
with this medication. Zoloft should not be taken within two
weeks of thioridazine. Patients over 65 years of age should allow a
longer wait period between using Zoloft and thioridazine, as
Zolof may stay in their system longer than in other patients.
- Tranquilizers such as haloperidol or chlorpromazine may cause oversedation.
- Tricyclic antidepressants such as amitriptyline, amoxapine, clomipramine, desipramine, doxepin, imipramine, nortriptyline, protriptyline,
and trimipramine, may increase the risk of side
effects from Zoloft.
- Tryptophan or 5-HTP - This supplement may increase the
risk of serotonin syndrome when mixed with Zoloft.
- Sildenafil -
Increased risk of side effects.
- May increase risk of serious side effects from bupropion.
Talk with your doctor if you are considering mixing an
antidepressant like Zoloft with any other antidepressant, or any
medication that may cause drowsiness. Antidepressant medication can
have increased, unexpected, or severe side effects when mixed with
other medications that affect the central nervous system.
The usual starting dose of Zoloft is 25-50 mg per day, up to a
maximum of 200 mg per day. Since Zoloft stays in the body for 24
hours, doses should be taken at the same time every day. Do not take
double doses of Zoloft, and ask your doctor what to do about missed
doses. Dosage should be increased at minimum intervals of a week,
and stopped slowly according to your doctor's advice. Zoloft should
not be abruptly started or stopped.
Zoloft is normally taken once a day, and can be taken with or without food. If you miss a dose, do not take a double dose the following day. Zoloft may take several weeks to improve your condition.
Zoloft should be stopped slowly, by gradually decreasing dosage as directed by your doctor. Suddenly stopping treatment can cause increased side effects.
Keep Zoloft away from children; both when storing it, and when discarding any unused medication.
Zoloft has not been shown to cause damage to the fetus during
pregnancy, but it has not been fully studied in humans and proven
safe. Advise your doctor if you are pregnant, or are planning a
pregnancy if you are considering taking Zoloft. The manufacturer
recommends that Zoloft be taken during pregnancy only if the benefit
justifies the possible risk to the fetus.
Trace amounts of Zoloft pass through breast milk, but have not
been demonstrated to be harmful to nursing babies. The long term
effects are unknown and caution is advised.
Zoloft has not been studied for use in children under 6.
Zoloft has been prescribed as a treatment for obsessive
compulsive disorders in children from 6-17 years of age. The
starting dose of Zoloft for children 6-12 is usually 25 mg, up to
200 mg per day. The starting dose of Zoloft for children 13-17 is
usually 50 mg, up to 200 mg per day.
Zoloft has not been observed to have different effects in the
elderly than in the general population, but it appears to stay in
the system longer. Patients 65 years or older should try a lower
starting dose of Zoloft, 12.5 mg per day is common.
This document is provided for information only. It is not a
substitute for consultation with a physician, either to diagnose
symptoms or prescribe treatment. Any dosages mentioned are general
guidelines only, please follow the directions of your doctor exactly when taking
Zoloft. We have made every effort
to ensure that this information is accurate, but only your doctor can say if Zoloft, or a drug combination, is safe for you. It
should not be construed to indicate that to buy and use Zoloft is
safe, appropriate, or effective for you. Consult your healthcare
professional before you order Zoloft online.